BREZTRI is indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD).

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BREZTRI is not indicated for the relief of acute bronchospasm or for the treatment of asthma.

BREZTRI significantly reduced the annual rate of moderate or severe COPD exacerbations vs LAMA/LABA (RR=0.76; 95% CI: 0.69, 0.83; P<0.0001) and ICS/LABA (RR=0.87; 95% CI: 0.79, 0.95; P=0.0027) in a 52-week study.1* Annual rate estimate: BREZTRI 1.08; LAMA/LABA: 1.42; ICS/LABA 1.24.1

*Moderate exacerbations were defined as those leading to treatment with systemic corticosteroids and/or antibiotics, and severe exacerbations were defined as those resulting in hospitalization or death.

RR=rate ratio.

BREZTRI IS FOR PATIENTS WITH COPD REGARDLESS OF THEIR RECENT EXACERBATION HISTORY.1-4†

BREZTRI was studied in symptomatic patients with and without a history of moderate or severe exacerbations in the previous year.

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