Unbranded disease information. These endpoints were not studied for BREZTRI.

PATIENTS WITH COPD NEED PROTECTION FROM THE DANGERS OF EXACERBATIONS1-4

Risk of COPD Hospitalization Increased by 21%
Risk of COPD Hospitalization Increased by 21%

JUST 1 MODERATE EXACERBATION INCREASED THE RISK OF A FUTURE COPD HOSPITALIZATION* BY 21%2†

*For severe COPD exacerbation.

21% increase comparing patients with 1 moderate acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with those who had no AECOPD.

In patients with COPD who had cardiovascular disease (CVD) or multiple risk factors for CVD

RISK OF A CARDIOVASCULAR EVENT INCREASED BY 10x FOLLOWING A COPD HOSPITALIZATION3*

*For severe COPD exacerbation.

In the first 30 days following the onset of an acute exacerbation.

Risk of Cardiovascular Event Increased by 10%
Risk of Cardiovascular Event Increased by 10%
1 in 2 patients died within 3.6 years after their first COPD Hospitalization
1 in 2 patients died within 3.6 years after their first COPD Hospitalization

1 IN 2 PATIENTS DIED WITHIN 3.6 YEARS AFTER THEIR FIRST COPD HOSPITALIZATION4*§

*For severe COPD exacerbation.



Data from a UK population-based study of ~100,000 patients with COPD (up to 10 years of follow-up). Severe exacerbations were defined as those requiring hospitalization and moderate exacerbations were defined as those managed outside the hospital.

A post hoc analysis of the multinational SUMMIT trial (N=16,485) was performed to determine whether the risk for cardiovascular events increases after a moderate/severe COPD exacerbation. Acute exacerbations of COPD were defined as an increase in respiratory symptoms requiring treatment with antibiotics, systemic corticosteroids, and/or hospitalization.

§Cohort study that evaluated severe COPD exacerbations and their association with mortality in 73,106 patients with their first severe COPD exacerbation requiring hospitalization in the Régie de l’assurance maladie du Québec from the health insurance program of the province of Québec, Canada. Severe exacerbations were defined as hospitalization with a primary discharge diagnosis of COPD.

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